Name: Dr. Abbas Hassan
Designation: Associate Professor
Department: Chemistry
Qualifications: PhD, University of Texas at Austin

Austin TX USA
Phone: +92-51 9064-2107
Status: On job
Other Weblink:

Research Interests/Publications/Conferences/Research Projects

Specialization: Organic Chemistry

Research Areas/Areas of Expertise:

Transition metal catalysis, Asymmetric catalysis.

Instrumentation Available (Focal Person):

Chiral HPLC

Recent Publications:

  • “Investigation of new quinoline derivatives as promising inhibitors of NTPDases: Synthesis, SAR analysis and molecular docking studies”

Hayat, K.; Afzal, S.; Saeed, A.; Murtaza, A.; Rahman, S.U.; Khan K. M.; Saeed, A.; Zaib, S.; Lecka, J.; Sévigny, J.; Iqbal, J.; Hassan, A. Bioorg. Chem. 2019, 87, 218-226,

(IF 3.929)

  • “Design, Synthesis and Bioevaluation of Tricyclic Fused Ring System as Dual Binding Site Acetylcholinesterase Inhibitors”

Tanoli, S. T.; Ramzan, M.; Hassan, A.; Sadiq, A.; Jan, M. S.; Khan, F. A.; Ullah, F.; Ahmad, H.; Bibi, M.; Rashid, U. Bioorg. Chem. 2019, 83, 336-347.

(IF 3.929)

  • Current Progress in Nitrogen Based Chiral Ligands for Pd-catalyzed Asymmetric Transformations”

Khan, I U.; Bibi, R.; Hassan, A. Curr. Org. Chem. 2018, 22, 2460-2486.

(IF 2.193)

  • “Sensitive and Selective Detection of Multiple Metal Ions Using Amino Acids Modified Glassy Carbon Electrodes”

Nisar, A.; Shah, A.; Zahid, A.; Iftikhar, F. J.; Hassan, A.; Shah, A. H.; She, Z.; Akhter, M. S.; Piro, B.; Kraatz, H. B. J. Electrochem. Soc., 2018, 165, B67-B73.

(IF 3.662)

  • “Modification of Bischler-Möhlau Indole Derivatives through Palladium Catalyzed Suzuki Reaction as Effective Cholinesterase Inhibitors, their Kinetic and Molecular Docking Studies”

Parveen, S.; Shah, M. S.; Zaib, S.; Gul, T.; Khan, K. M.; Iqbal, J.; Hassan, A. Bioorg. Chem. 2018, 76, 166-176.

(IF 3.929)

  • Pd-PEPPSI-IPent-SiO2, a Supported Catalyst for Challenging Negishi Coupling Reactions in Flow”

Price, G. A.; Hassan, A.; Bogdan, A. R.; Djuric S. W.; Organ, M. G. Angew. Chem. Int. Ed. 2017, 129, 13532-13350.

(IF 12.102)

  • “Design, Synthesis, in vitro Evaluation and Docking Studies on Dihydropyrimidine-Based Urease Inhibitors”

Iftikhar, F.; Ali, Y.; Kiani, F. A.; Hassan, S. F.; Fatima, T.; Khan, A.; Niaz, B.; Hassan, A.; Ansari, F. L.; Rashid U. Biorg. Chem. 2017, 74, 53-65.

(IF 3.929)

  • “Chemo-, Regio-, and Enantioselective Rhodium Catalyzed Allylation of Pyridazinones with Terminal Allenes”

Parveen, S.; Li, C.; Hassan, A.; Breit, B.; Org. Lett. 2017, 19, 2326-2329.

(IF 6.492)

  • “Enantioselective total synthesis of the highly selective sphingosine-1-receptor VPC01091 by the Heck desymmetrization of a non-activated cyclopentene-fused spiro-pyrrolidinone”

Khan, I. U.; Kattela, S.; Hassan, A.; Correia, C. R. D. Org. Biomol. Chem. 2016, 14, 9476-9480.

(IF 3.423)                    Highlighted in Synfacts 2017, 16

  • “Anticancer activity, DNA-binding and DNA-denaturing aptitude of palladium(II) dithiocarbamates”

Amir, M. K.; Khan, S. Z.; Hayat, F.; Hassan, A.; Butler, I. S.; Rehman, Z. U.; Inorg. Chim. Acta 2016, 451, 31-40. (IF 2.264)

  • “Humidity-Sensing and DNA Binding Ability of Bis(4-benzylpiperazine-1-carbodithioato-K2S,S)Nickel(II)”

Rehman, M. U.; Imran, M.; Rehman, Z. U.; Hassan, A.; Badshah, A.; Shah, A.; Tahir, M. N.; Shah, G. J. Coord. Chem. 2015, 68, 295-307.

(IF 1.703)

  • “Enantioselective Conversion of Primary Alcohols to α-Methylene γ-Butyrolactones via Iridium Catalyzed C-C Bond Forming Transfer Hydrogenation: 2-(Alkoxycarbonyl)allylation”

Montgomery, T. P.; Hassan, A.; Park, B. Y.; Krische, M. J. J. Am. Chem. Soc. 2012, 134. 11100-11103.

(IF 14.357)

  • “Consecutive Iridium Catalyzed C-C and C-H Bond Forming Hydrogenations for the Diastereo- and Enantioselective Synthesis of syn-3-Fluoro-1-Alcohols: C-H (2-Fluoro)allylation of Primary Alcohols”

Hassan, A.; Montgomery, T. P.; Krische, M. J.  Chem. Commun., 2012, 47, 4692-4694.

(IF 6.290)                    Highlighted in Synfacts 2012, 869.

  • “Unlocking Hydrogenation for C-C Bond Formation: A Brief Overview of Enantioselective Methods”

Hassan, A.; Krische, M. J. Org. Process Res. Dev. 2011, 15, 1236-1242.

(IF 3.584)

  • “Catalytic Enantioselective Grignard Nozaki-Hiyama Methallylation from the Alcohol Oxidation Level: Chloride Compensates for π-Complex Instability”

Hassan, A.; Townsend, I. A.; Krische, M. J. Chem. Commun. 2011, 47, 10028-10030.

(IF 6.290)                    Highlighted in Synfacts 2011, 1206.

  • “Enantioselective Vinylogous Aldol-Reformatsky Addition from the Alcohol or Aldehyde Oxidation Level via Iridium Catalyzed Transfer Hydrogenation: Linear Regioselectivity by Way of C-Bound Iridium Enolates”

Hassan, A.; Zbieg, J. R.; Krische, M. J. Angew. Chem. Int. Ed. 2011, 50, 3493-3496.

(IF 12.102)                  Highlighted in Synfacts 2011, 741.

  • “Total Synthesis of (+)-Roxaticin: A Departure from Stoichiometric Chiral Reagents, Auxiliaries and Premetallated Nucleophiles in Polyketide Construction”

Han, S. B.; Hassan, A.; Kim, I.-S.; Krische, M. J. J. Am. Chem. Soc. 2010, 132, 15559-15561.

(IF 14.357)                  Highlighted in Synfacts 2011, 121.

  • “Elongation of 1,3-Polyols via Iterative Catalyst-Directed Carbonyl Allylation from the Alcohol Oxidation Level”

Hassan, A.; Lu, Y.; Krische, M. J. Org. Lett. 2009, 11, 3112-3115.

(IF 6.492)


  • “1,n-Glycols as Dialdehyde Equivalent in Iridium Catalyzed Enantioselective Carbonyl Allylation form the Alcohol Oxidation Level and Iterative Two-Directional Assembly of 1,3-Polyols”

Lu, Y.; Kim, I.-S.; Hassan, A.; Del Valle, D. J.; Krische, M. J. Angew. Chem. Int. Ed. 2009, 48, 5018-5021.

(IF 12.102)                  Highlighted in Synfacts 2009, 997.

  • “Diastereo- and Enantioselective Reductive Aldol Addition of Vinyl Ketones via Catalytic Hydrogenation”

Han, S. B.; Hassan, A.; Krische, M. J. Synthesis 2008, 2669-2679.

(IF 2.722)

  • “Diastereo- and Enantioselective Hydrogenative Aldol Coupling of Vinyl Ketones: Design of an Effective Monodentate TADDOL-Like Phosphonite Ligand”

Bee C.; Han, S. B.; Hassan, A.; Iida, H.; Krische, M. J. J. Am. Chem. Soc. 2008, 130, 2746-2747.

(IF 14.357)                  Highlighted in Synfacts 2008, 596.

Courses Taught: ……………………………………..

MPhil/PhD Advance Stereoselective Synthesis CH-658, Medicinal Chemistry CH-656, Natural Products Synthesis CH-636, Advance Synthesis and Catalysis CH-635

MSc Organic Chemistry-I CH-341, Chemistry of Natural Products CH-443, Name Reactions CH-471, Reaction Mechanism-I CH-441, Reaction Mechanism-II CH-444, Spectroscopic Methods in Organic Chemistry-II (NMR Spectroscopy) CH-474.