Name: Dr. Ahsanullah
Designation: Assistant Professor
Department: Chemistry
Qualifications: Ph.D (Freie University Berlin, Germany)

Postdoc (Sanford Burnham Institute, California, USA)

Postdoc (University of Montreal, Canada)

Phone: +92-51 9064-2109
Email: ahsan@qau.edu.pk
Status: On Job
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Research/Interests/Publications/Conferences/Research Projects

Specialization:

Bioorganic Chemistry

Research Areas/Areas of Expertise:

Medicinal Chemistry of Peptides, Peptidomimetics and Heterocycles

Awards and Grants:

HEC/DAAD Ph.D Scholarship

HEC Grant:

Synthesis and biological screening of tetrazole derivatives and tetrazole-based peptidomimetics as antimicrobial agents

Recent Publications:

  1. Aza-propargylglycine installation by aza-amino acylation: Synthesis and Ala-scan of an azacyclopeptide CD36 modulator; Peptide Science 2019, 111, e24102.
  2. Chemoselective Wittig and Michael Ligations of unprotected peptidyl phosphoranes in water furnish potent Inhibitors of Caspase‑3;

Org. Lett. 2014, 16, 4428-4431.

  1. miR-TRAP: A benchtop chemical biology strategy to identify microRNA targets;

Angew. Chem., Int. Ed. 2012, 51, 5880-5883.

  1. Soluble peptidyl-phosphoranes for mrtal-free, regioselective, ligations in organic and aqueous solution Org. Lett. 2012, 14, 14-17.
  2. Peptidyl-heterocycle-chimera: new classes of more drug-like peptidomimetics by ligations of peptide bis-electrophiles with various bis-nucleophiles;

Eur. J. Org. Chem. 2011, 4, 730-739.

  1. Cyclative cleavage via dipolar cycloaddition: polymer bound azidopeptidyl-phosphoranes deliver locked cis-triazolyl-cyclopeptides as privileged protein binders; Angew. Chem., Int. Ed. 2010, 49, 5378-5382.
  2. Efficient access to peptidyl ketone and peptidyl diketones via Calkylation and C-acylation of polymer-supported phosphorous ylides followed by hydrolytic or/and oxidative cleavage; Peptides Science 2010, 94, 220-228.
  3. Biocompatible Triazole Ligations via 1,3-Dipolar Cycloadditions of Peptidyl Phosphoranes and Azido Peptides; Proceedings of the 31st European Peptide Symposium 2010, 30-31.
  4. Metal-free, regioselective triazole ligations that deliver locked cis peptide mimetics; Angew. Chem., Int. Ed. 2009, 48, 5042-5045.
  5. In silico studies of urease inhibitors to explore ligand-enzyme interactions;

Journal of Enzyme Inhibition and Medicinal Chemistry 2009, 24, 151- 156.

  1. Microwave assisted synthesis, antibacterial activity against Bordetella

Bronchiseptica of a library of 3-hydroxyaryl and heteroaryl chalcones

and molecular descriptors-based SAR; ARKIVOC 2009, 318-332.

  1. Combinatorial Synthesis, Lead Identification and Antitumor Study of

Chalcone-Based Positional-Scanning Library; Chemistry & Biodiversity 2007, 4, 203-214.

Patents:

Novel cyclic peptides and uses thereof, Provisional patent No. US 62/355,496, filed June 28, 2016.

Courses Taught:

Advance Stereochemistry, Chemistry of Heterocycles, Functional Groups Chemistry