Research Areas/Areas of Expertise:
Medicinal Chemistry of Peptides, Peptidomimetics and Heterocycles
Awards and Grants:
HEC/DAAD Ph.D Scholarship
Synthesis and biological screening of tetrazole derivatives and tetrazole-based peptidomimetics as antimicrobial agents
- Aza-propargylglycine installation by aza-amino acylation: Synthesis and Ala-scan of an azacyclopeptide CD36 modulator; Peptide Science 2019, 111, e24102.
- Chemoselective Wittig and Michael Ligations of unprotected peptidyl phosphoranes in water furnish potent Inhibitors of Caspase‑3;
Org. Lett. 2014, 16, 4428-4431.
- miR-TRAP: A benchtop chemical biology strategy to identify microRNA targets;
Angew. Chem., Int. Ed. 2012, 51, 5880-5883.
- Soluble peptidyl-phosphoranes for mrtal-free, regioselective, ligations in organic and aqueous solution Org. Lett. 2012, 14, 14-17.
- Peptidyl-heterocycle-chimera: new classes of more drug-like peptidomimetics by ligations of peptide bis-electrophiles with various bis-nucleophiles;
Eur. J. Org. Chem. 2011, 4, 730-739.
- Cyclative cleavage via dipolar cycloaddition: polymer bound azidopeptidyl-phosphoranes deliver locked cis-triazolyl-cyclopeptides as privileged protein binders; Angew. Chem., Int. Ed. 2010, 49, 5378-5382.
- Efficient access to peptidyl ketone and peptidyl diketones via Calkylation and C-acylation of polymer-supported phosphorous ylides followed by hydrolytic or/and oxidative cleavage; Peptides Science 2010, 94, 220-228.
- Biocompatible Triazole Ligations via 1,3-Dipolar Cycloadditions of Peptidyl Phosphoranes and Azido Peptides; Proceedings of the 31st European Peptide Symposium 2010, 30-31.
- Metal-free, regioselective triazole ligations that deliver locked cis peptide mimetics; Angew. Chem., Int. Ed. 2009, 48, 5042-5045.
- In silico studies of urease inhibitors to explore ligand-enzyme interactions;
Journal of Enzyme Inhibition and Medicinal Chemistry 2009, 24, 151- 156.
- Microwave assisted synthesis, antibacterial activity against Bordetella
Bronchiseptica of a library of 3-hydroxyaryl and heteroaryl chalcones
and molecular descriptors-based SAR; ARKIVOC 2009, 318-332.
- Combinatorial Synthesis, Lead Identification and Antitumor Study of
Chalcone-Based Positional-Scanning Library; Chemistry & Biodiversity 2007, 4, 203-214.
Novel cyclic peptides and uses thereof, Provisional patent No. US 62/355,496, filed June 28, 2016.
Advance Stereochemistry, Chemistry of Heterocycles, Functional Groups Chemistry